Heterogeneity of changes in executive cognitive functions in people with different alcohol use experiences


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Abstract

Executive functions are multidimensional cognitive processes, which are provided by prefrontal cortex of the brain and are involved in initiation and regulation of goal-oriented behavior. Current studies are showing that changes in executive functioning can be predictive for alcohol consumption, which, considering high social significance of unsafe alcohol use and dependence, determines the importance of the research on this issue. Results presented in this paper were obtained through validated methods for executive function assessment on a sample of 133 people with varied drinking experience, including 41 people with safe alcohol use and 92 with a diagnosed alcohol dependence. The study showed that people with alcohol dependence had significant changes in executive functions indicators, including those of cognitive control, cognitive flexibility, attention, and working memory, which were not observed in people with safe alcohol use. Changes in executive functions of people with alcohol dependence were found to be heterogeneous – 43.5 % of the surveyed with alcohol dependence had more pronounced impairments in attention with a fourfold increase in switching errors, which were also associated with higher impulsivity, non-adaptive emotional coping and a shorter remission. Results on the heterogeneity of executive functions in people with alcohol dependence expand the understanding of executive functioning and its dynamics in adulthood under the influence of various factors. Associations of pronounced attention impairments in alcohol dependence with impulsivity, emotional coping, and the duration of remission may advance psychological intervention including diagnostic and rehabilitation methods.

About the authors

Anastasia Grigorievna Peshkovskaya

Tomsk State University, Tomsk
Tomsk National Research Medical Center of the RAS, Tomsk

Author for correspondence.
Email: peshkovskaya@gmail.com
ORCID iD: 0000-0002-3951-395X

Director of Neurosciences Center, researcher of Mental Health Research Institute

Russian Federation

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